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Neuroblastoma Associated Transcript 1 (NBAT1) is downregulated in high-risk patient group
Neuroblastoma Associated Transcript 1 (NBAT1) is downregulated in high-risk patient group
Volcano plot showing NBAT1 lncRNA downregulated in high-risk MYCN-amplified tumors compared to low-risk patients. Box plot with expression levels of NBAT1 in low-risk, 11q-deleted and high-risk (MYCN-amplified) patients.
NBAT1 knockdown affects cell proliferation and migration
NBAT1 knockdown affects cell proliferation and migration
Volcano plot showing genes deregulated upon NBAT1 knockdown in SH-SY-5Y cells. Highlighted genes related to cell differentiation (SOX9) and neuronal differentiation genes (REST/NRSF, neuronal repressor), are upregulated. Network plots with cell migration and proliferation processes affected by NBAT1 knockdown.
NBAT1 knockdown in differentiated cells impairs neuronal differentiation
NBAT1 knockdown in differentiated cells impairs neuronal differentiation
Pathways associated with genes (n=455) that are downregulated upon NBAT1 knockdown in retinoic acid induced (neuronal) differentiated SH-SY-5Y cells in day 4 and day 7 compared with day 0.Among these, 166 genes were having REST/NRSF (neuronal repressor) binding sites. Model explaining how NBAT1 regulates neuronal differentiation in neuroblastoma.
Note: Above findings are published in Cancer Cell, Volume 26, Issue 5 (Pandey G et al, 2014). Only computational analysis results contributed by me is included in above summary. For complete research, please have a look at this original article.
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